Can I take Amitriptyline and Raberazole together?

Why this happens

Rabeprazole is a proton pump inhibitor (PPI) that can interfere with the liver enzymes (specifically CYP2C19 and CYP3A4) responsible for breaking down amitriptyline. This can lead to the antidepressant staying in your system for longer.

This combination is generally considered safe, but you should be mindful of any increased side effects. If you feel unusually sleepy, dizzy, or notice a change in your heart rhythm, speak to your doctor. They may choose to monitor you more closely or adjust your dose if necessary.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.