Can I take Amitriptyline and Quinine bisulfate bp together?

Why this happens

Both amitriptyline and quinine can affect the electrical activity of the heart. When used together, they have an 'additive effect', meaning they both slow down the heart's electrical recharging system at the same time, making a dangerous heart rhythm more likely.

You must speak to your doctor before taking these two medicines together. They may want to perform an ECG (heart trace) to check your heart rhythm or consider an alternative treatment for your leg cramps or pain. Seek immediate medical help if you experience a very fast or pounding heartbeat, severe dizziness, or fainting while taking these medications.

Heart rhythm disorders (e.g., Long QT syndrome)

Quinine can cause serious, potentially fatal heart rhythm problems. You must not take this if you have a history of heart rhythm issues or are taking other medicines that affect your heart rate.

Suicidal thoughts and depression

This medicine can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment or when the dose is changed. Seek immediate medical help if your mood worsens or you have distressing thoughts.

Tinnitus or hearing loss

Stop taking this medicine immediately and contact your doctor if you experience ringing in the ears (tinnitus), hearing loss, or dizziness, as these can be signs of quinine toxicity.

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Grapefruit juice

Grapefruit juice can increase the level of quinine in your blood, which may increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.