Can I take Amitriptyline and Eliquis together?
Drug interaction guide
Originally published 12 May 2026
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Taking amitriptyline and Eliquis (apixaban) together may increase your risk of bleeding. This includes bruising more easily, nosebleeds, or more serious internal bleeding.
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Why this happens
Amitriptyline can interfere with how platelets (the cells that help your blood clot) work. Since Eliquis is a blood thinner designed to prevent clots, combining the two can make it much harder for your body to stop any bleeding that occurs.
What you should do
Back to contentsUse this combination with caution. You should inform your doctor if you are taking both. Seek medical help immediately if you notice signs of serious bleeding, such as blood in your urine, black or tarry stools, coughing up blood, or severe bruising that appears for no reason.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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