Can I take Amitriptyline and Codeine extra together?

Why this happens

Both medicines affect the central nervous system (the brain). Amitriptyline is a tricyclic antidepressant and codeine is an opioid painkiller. When used together, their sedative effects add up (a 'synergistic' effect). Additionally, amitriptyline can slow down the gut, which increases the risk of constipation caused by codeine.

You should only take these two medicines together if your doctor is aware and has specifically prescribed both. If you do take them together, avoid driving or operating machinery until you know how they affect you. Avoid alcohol, as this will make the sleepiness much worse. Seek medical help immediately if you experience extreme slow breathing or cannot stay awake.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.