Skip to main content

Can I take Alendronic acid and Apixaban together?

Drug interaction guide

Taking alendronic acid and apixaban together can increase your risk of developing irritation, inflammation, or ulcers in your food pipe (oesophagus) and stomach. If these ulcers occur, apixaban (a blood thinner) may cause them to bleed more severely.

Video picks for Drug interactions

Continue reading below

Why this happens

Alendronic acid is known to be very irritating to the lining of the digestive tract. Apixaban prevents blood clots, which means if the alendronic acid causes any small cuts or ulcers in the stomach or food pipe, they are much more likely to bleed and will be harder for the body to heal.

You can take both, but you must follow the instructions for alendronic acid very strictly: take it first thing in the morning with a full glass of plain water, stay upright (sitting or standing) for at least 30 minutes, and do not eat anything during this time. If you develop any new indigestion, heartburn, pain when swallowing, or if you notice black, tarry stools, contact your doctor immediately.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.