Can I take Alcohol and Norco together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Combining alcohol with Norco (hydrocodone and paracetamol) is extremely dangerous. It can lead to severe drowsiness, slowed or stopped breathing, coma, and even death. Additionally, both alcohol and the paracetamol in Norco can damage the liver; taking them together significantly increases the risk of acute liver failure.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both alcohol and hydrocodone (the opioid in Norco) are central nervous system depressants, meaning they slow down brain activity and the signals that tell your body to breathe. When taken together, these effects are multiplied (synergistic). Furthermore, alcohol changes how the liver processes paracetamol, leading to the buildup of toxic substances that destroy liver cells.
What you should do
Back to contentsDo not drink any alcohol while taking Norco. If you have accidentally combined them and feel excessively sleepy, dizzy, or have difficulty breathing, seek emergency medical help immediately. Always inform your doctor if you have a history of heavy alcohol use before starting this medication.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Aspirin and Tramadol together?
Taking aspirin and tramadol together can increase the risk of bleeding, particularly in the stomach or gut. It may also increase the risk of side effects like dizziness, drowsiness, or feeling sick. Additionally, both medications can affect your kidney function, especially if you are dehydrated or have existing kidney issues.

Drug interactions checker
Can I take Amlodipine and Ramipril together?
Taking these two medicines together can cause your blood pressure to drop lower than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. It can also increase the risk of your kidneys not working as well as they should or cause a rise in potassium levels in your blood.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.