Can I take Agomelatine and Mounjaro kwikpen together?
Drug interaction guide
Originally published 12 May 2026
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There is no known direct interaction between agomelatine and Mounjaro (tirzepatide). However, Mounjaro slows down how quickly your stomach empties, which could theoretically change how quickly your body absorbs other tablets like agomelatine.
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Why this happens
Mounjaro is a GLP-1 and GIP receptor agonist that delays 'gastric emptying' (the speed at which food and medicine leave the stomach). Agomelatine is an antidepressant that is absorbed through the digestive system. While no specific problems have been reported, any medicine that slows the stomach could potentially delay the time it takes for agomelatine to start working.
What you should do
Back to contentsYou can generally take these two medicines together. Because Mounjaro can affect your digestion, pay attention to whether your mood or sleep patterns change when you start or increase your dose of Mounjaro. If you feel your antidepressant is not working as well as usual, or if you experience new side effects, speak to your doctor.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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