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Can I take Adizem and Gabapentin together?

Drug interaction guide

Taking Adizem (diltiazem) and gabapentin together can increase the risk of side effects such as extreme sleepiness, dizziness, and a feeling of being 'spaced out'. In some cases, it may also lead to increased swelling in the legs or ankles (oedema).

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Why this happens

Both medications can slow down the central nervous system, leading to an additive sedative effect. Additionally, diltiazem may slightly interfere with how the body processes certain medications, potentially increasing the levels of gabapentin in your system, though the main concern is the combined effect on your alertness and balance.

Use caution when starting this combination. Avoid driving or operating heavy machinery until you know how these medicines affect you together. If you experience severe drowsiness, confusion, or significant swelling in your legs, contact your GP. Your doctor may need to adjust your doses.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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