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Can I take Acetazolamide and Biquelle together?

Drug interaction guide

Taking acetazolamide and Biquelle (quetiapine) together can increase the risk of certain side effects. Both medicines can cause drowsiness, dizziness, and a drop in blood pressure when you stand up (postural hypotension), which may lead to falls. Additionally, acetazolamide can affect the levels of salts (electrolytes) in your blood, which may increase the risk of a rare but serious heart rhythm problem associated with quetiapine.

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Why this happens

Both drugs have 'central nervous system' depressant effects, meaning they slow down brain activity, leading to increased sleepiness. Acetazolamide is a diuretic (water tablet) that can lower potassium levels in the blood; low potassium increases the risk of quetiapine causing a heart rhythm disturbance known as QT prolongation.

You should use this combination with caution. It is important to have regular blood tests to monitor your salt levels (especially potassium and magnesium) as directed by your doctor. If you feel dizzy, confused, or notice a racing or fluttering heartbeat, seek medical advice immediately. Avoid or strictly limit alcohol, as it will make the drowsiness much worse.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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