Can I take Acetazolamide and Amitriptyline together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can increase the risk of certain side effects. You may feel more drowsy, dizzy, or confused than usual. There is also a small risk that the levels of amitriptyline in your blood could rise, or that your potassium levels could drop too low.
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Why this happens
Acetazolamide can make your urine less acidic (more alkaline). This change can sometimes slow down how quickly the body gets rid of amitriptyline, potentially leading to higher levels of the drug in your system. Additionally, both drugs can affect your heart rhythm or electrolyte balance (like potassium), and both can cause drowsiness.
What you should do
Back to contentsUse caution when taking these medicines together. If you feel unusually sleepy, dizzy, or notice a fluttering heart beat, contact your doctor. Your doctor may want to monitor your potassium levels or adjust your doses. Do not drive or operate machinery until you are sure you are not feeling drowsy or confused.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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