Can I take 7.5mg and Co-codamol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking zopiclone and co-codamol together can make you feel extremely sleepy, dizzy, and confused. It can also cause your breathing to become very slow or shallow, which can be dangerous.
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Why this happens
Both zopiclone and the codeine in co-codamol are 'central nervous system depressants'. This means they both slow down brain activity and the signals that control breathing. When taken together, these effects add up and become much stronger.
What you should do
Back to contentsYou should only take these two medicines together if your doctor has specifically told you to do so and is aware you are taking both. If you do take them together, avoid alcohol, do not drive or operate machinery, and ensure someone is with you to monitor your breathing. Seek medical help immediately if you feel unusually drowsy or have difficulty breathing.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.

Treatment and medication
Can I take 150 and Zigduo together?
Taking aspirin (75mg to 150mg) with Xigduo (which contains dapagliflozin and metformin) can increase the risk of your blood sugar dropping too low (hypoglycaemia). It may also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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