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Can I take 50xl and Aspirin together?

Drug interaction guide

Taking these two medicines together significantly increases your risk of internal bleeding, particularly in the stomach or gut. It can also lead to serious kidney problems.

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Why this happens

Both medicines belong to a group called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). They work by blocking certain enzymes in the body. When you take two different NSAIDs together, you 'double up' on the side effects without getting extra pain relief. This thins the stomach lining and reduces blood flow to the kidneys.

Do not take these two medicines together. If you have been prescribed both by a doctor, speak to them or a pharmacist immediately before taking another dose. If you experience severe stomach pain, black tarry stools, or vomit that looks like coffee grounds, seek emergency medical help.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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