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Can I take 50 and Levothyroxine together?

Drug interaction guide

Taking 5-HTP and levothyroxine together may lead to an excessive increase in serotonin levels in the brain. This can cause a rare but serious condition called serotonin syndrome. Symptoms can include shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, if your thyroid levels are not well-controlled, 5-HTP might affect your heart rate or blood pressure.

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Why this happens

Levothyroxine (thyroid hormone) can increase the sensitivity of receptors in the brain to serotonin. 5-HTP is a building block that the body uses to produce more serotonin. When used together, the thyroid hormone can 'supercharge' the effect of the extra serotonin produced by the 5-HTP, potentially leading to dangerously high levels of serotonin activity.

You should speak to your doctor or pharmacist before taking 5-HTP if you are on levothyroxine. It is generally best to avoid this combination unless specifically supervised by a healthcare professional. If you are already taking both and feel unwell, agitated, or have a very fast heartbeat, seek medical advice immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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