Can I take 50 and Glucosamine complex with msm together?
Drug interaction guide
Originally published 14 Mar 2026
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There is a potential risk of increased bleeding when taking glucosamine alongside blood-thinning medications like warfarin. While the interaction with other medications is less common, glucosamine may also slightly affect blood sugar levels. MSM (Methylsulfonylmethane) generally has a good safety profile but can occasionally cause stomach upset or headaches when combined with other supplements.
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Why this happens
Glucosamine may enhance the effects of anticoagulant (blood-thinning) drugs, though the exact biological reason is not fully understood. It may also interfere with how the body processes sugar (insulin sensitivity). MSM is an organosulphur compound that does not have many well-documented chemical interactions but can have additive side effects on the digestive system.
What you should do
Back to contentsIf you are taking any blood-thinning medication (like warfarin) or medication for diabetes, you must speak to your doctor or pharmacist before starting this supplement. Monitor for any unusual bruising or bleeding. If you are scheduled for surgery, stop taking glucosamine at least two weeks beforehand.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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