Can I take 40 and Mebeverine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There are no known interactions between paracetamol and mebeverine. They are commonly taken together to manage symptoms of Irritable Bowel Syndrome (IBS), such as stomach cramps and pain.
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Why this happens
These medicines work in different ways and do not interfere with how the body absorbs, breaks down, or removes either drug. Paracetamol is a painkiller that works on the central nervous system, while mebeverine is an antispasmodic that works directly on the muscles in the gut to help them relax.
What you should do
Back to contentsIt is safe to take these two medicines together. However, it is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. Always follow the dosage instructions on the packaging for both medicines.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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