Can I take 25 and Concerta together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Combining alcohol with Concerta (methylphenidate) can cause the medication to be released into your bloodstream too quickly. This can lead to an increase in side effects such as a racing heart, high blood pressure, anxiety, and sleep problems. Alcohol can also mask the effects of Concerta, making you feel less intoxicated than you actually are, which increases the risk of alcohol poisoning or accidents.
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Why this happens
Alcohol can change how the body breaks down the 'extended-release' system of Concerta, potentially causing a large dose of the drug to be released all at once (known as 'dose dumping'). Additionally, because Concerta is a stimulant and alcohol is a depressant, they compete in the central nervous system, hiding the typical signs of being drunk.
What you should do
Back to contentsIt is best to avoid or strictly limit alcohol while taking Concerta. You should be aware that drinking may increase the risk of heart-related side effects and may lead you to drink more than you intended because you do not feel the effects of the alcohol as quickly. If you choose to drink, do so very cautiously and do not drive.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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