Can I take 200 and Zigduo together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking these two medicines together can significantly increase the risk of your blood sugar dropping too low (hypoglycaemia). It can also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood. Additionally, both drugs can affect your kidney function, and taking them together may put extra strain on your kidneys.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both medicines work to lower blood sugar but in different ways. Celecoxib (the active ingredient in Celebrex 200) can sometimes interfere with how the body processes metformin (one of the ingredients in Xigduo), leading to higher levels of metformin in the blood. Celecoxib can also reduce blood flow to the kidneys, which makes it harder for the body to clear Xigduo.
What you should do
Back to contentsYou should speak to your doctor before taking these medicines together. If your doctor confirms you should take both, you must monitor your blood sugar levels very closely. Watch out for signs of low blood sugar, such as feeling shaky, sweaty, dizzy, or hungry. You should also stay well-hydrated to protect your kidneys. Seek medical help immediately if you feel unusually tired, have stomach pain, or have trouble breathing.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Desmopressin and Ketoconazole together?
Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.

Treatment and medication
Can I take Levothyroxine and Ramipril together?
There is no direct interaction between levothyroxine and ramipril. However, if your thyroid levels are not well-controlled, it can affect how well your blood pressure medication works.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.