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Can I take 100 and Testosterone cream together?

Drug interaction guide

Taking sildenafil (Viagra) and testosterone together can increase the risk of side effects related to your heart and blood pressure. Both medications can cause your blood vessels to widen, which may lead to headaches, dizziness, or a sudden drop in blood pressure when you stand up. Additionally, testosterone can sometimes increase the number of red blood cells, which might affect your circulation while using sildenafil.

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Why this happens

Sildenafil works by relaxing blood vessels (vasodilation) to improve blood flow. Testosterone also has effects on the cardiovascular system and can influence blood pressure and red blood cell production (erythrocytosis). When used together, their effects on the heart and blood vessels can be additive, potentially leading to lower blood pressure or increased strain on the heart.

You should use this combination with caution. Before starting sildenafil, ensure your doctor knows you are using testosterone cream. If you feel dizzy, lightheaded, or experience a racing heartbeat, sit or lie down immediately. It is important to have your blood pressure and red blood cell count monitored regularly by your doctor while using these treatments together.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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