Can I take 100 and Sulfasalazine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking aspirin and sulfasalazine together can increase the amount of sulfasalazine in your blood. This may increase your risk of experiencing side effects such as nausea, stomach upset, or headaches. Additionally, both medicines can be harsh on the stomach lining, which may increase the risk of stomach irritation or ulcers.
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Why this happens
Both aspirin and sulfasalazine belong to a family of medicines called salicylates. Because they are chemically similar, taking them together can lead to a 'double dose' effect. Aspirin can also compete with sulfasalazine for clearance from the body, leading to higher levels of the medicine in your system.
What you should do
Back to contentsYou should speak to your doctor before taking these two medicines together. They may want to monitor you more closely for side effects or adjust your dosage. If you experience any unusual stomach pain, indigestion, or dark/tarry stools, contact your doctor immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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