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Can I take 10 and Paracetamol together?

Drug interaction guide

Drinking alcohol while taking paracetamol increases the risk of serious liver damage. Even small amounts of alcohol can make the liver more vulnerable to the toxic by-products of paracetamol.

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Why this happens

The liver breaks down paracetamol into a toxic substance. Usually, the liver uses a protective antioxidant called glutathione to neutralise this toxin. Alcohol uses up the liver's supply of glutathione and can also cause the liver to produce more of the toxic substance, leading to liver cell death.

It is best to avoid or strictly limit alcohol when taking paracetamol. Never exceed the maximum recommended dose of paracetamol (usually 4g or eight 500mg tablets in 24 hours), and if you are a regular heavy drinker, you should speak to your doctor before taking paracetamol at all.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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