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Can I take 10 and Exemestane together?

Drug interaction guide

Taking St John's Wort (Hypericum perforatum) can significantly lower the amount of exemestane in your blood. This may make your cancer treatment less effective and increase the risk of the cancer returning or progressing.

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Why this happens

St John's Wort is a powerful 'inducer' of a liver enzyme called CYP3A4. This enzyme is responsible for breaking down exemestane in your body. By speeding up this process, St John's Wort causes the medicine to be cleared from your system much faster than intended.

Do not take St John's Wort while you are being treated with exemestane. If you are already taking it, speak to your doctor or oncologist immediately before stopping, as they may need to adjust your treatment plan. Always check with a pharmacist before starting any herbal supplements or over-the-counter medicines.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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