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Can I take 10 and Eliquis together?

Drug interaction guide

Taking cannabis (THC/CBD) with Eliquis (apixaban) can significantly increase your risk of serious bleeding. This includes internal bleeding that you cannot see, as well as bruising more easily or bleeding that is difficult to stop. Additionally, it is illegal to drive with any cannabis in your system in the UK.

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Why this happens

Cannabis can interfere with the enzymes in your liver that break down Eliquis. This causes the level of Eliquis in your blood to rise higher than intended. Furthermore, cannabis may have its own mild blood-thinning effects, which adds to the effect of the medicine.

You should avoid using cannabis while taking Eliquis. If you have used both, watch for signs of bleeding such as red or dark urine, black tarry stools, coughing up blood, or severe bruising, and seek medical help immediately. Do not drive, as it is illegal to do so with any cannabis in your system.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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