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Can I take 1.5mg and Perindopril together?

Drug interaction guide

Taking indapamide and perindopril together can cause your blood pressure to drop lower than intended, especially when you first start the combination or when your dose is increased. This may make you feel dizzy, lightheaded, or faint. It can also affect your kidney function and change the levels of salts (like potassium) in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways: indapamide is a 'water tablet' (diuretic) that removes excess salt and water, while perindopril is an ACE inhibitor that relaxes blood vessels. When used together, their effects add up. This combination can also put extra strain on the kidneys and lead to an imbalance of minerals in the body.

It is common for doctors to prescribe these two medicines together (sometimes in a single 'combination' pill), but you must be monitored closely. To stay safe:

  1. Take your first dose at bedtime to avoid dizziness during the day.

  2. Get up slowly from sitting or lying down.

  3. Attend all scheduled blood tests to check your kidney function and salt levels.

  4. It is best to avoid or strictly limit alcohol, as it can worsen the blood-pressure-lowering effect and increase dizziness.

  5. If you feel severely dizzy or faint, contact your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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