Can I take 1.25 and Citalopram together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking cannabis with citalopram can increase the risk of side effects like drowsiness, dizziness, and confusion. It may also increase the risk of a rare but serious condition called serotonin syndrome, which can cause a fast heartbeat, sweating, and muscle stiffness. Additionally, cannabis can sometimes make the symptoms of depression or anxiety worse, which may interfere with how well citalopram works for you.
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Why this happens
Both substances affect chemicals in the brain, particularly serotonin. Combining them can lead to an additive effect on the central nervous system. Furthermore, cannabis may interfere with the liver enzymes that break down citalopram, potentially leading to higher levels of the medicine in your blood.
What you should do
Back to contentsYou should speak to your doctor before using cannabis while taking citalopram. If you experience any unusual symptoms like extreme agitation, a very fast heartbeat, or severe confusion, seek medical help immediately. It is also important to note that it is illegal to drive with any cannabis in your system in the UK, regardless of whether you feel impaired.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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