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Can I take 0.35mg and Melatonin together?

Drug interaction guide

Taking melatonin while on the 'mini-pill' (progestogen-only pill) may increase the amount of melatonin in your body. This can make you feel much sleepier than usual, cause vivid dreams, or lead to a 'hangover' feeling the next morning. It might also slightly increase the risk of other melatonin side effects like headaches or dizziness.

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Why this happens

The progestogen in your contraceptive pill (norethisterone) can slow down how quickly your liver breaks down melatonin. This causes the melatonin levels to build up higher and stay in your system for longer than they normally would.

If you decide to use melatonin, start with the lowest possible dose. It is best to take it only when you are ready for bed and have a full night's sleep ahead of you. If you feel excessively drowsy the next day or experience severe headaches, stop taking the melatonin and speak with your GP or pharmacist.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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