Steroidi orali

What is an oral steroid?

Steroids are a type of hormone produced by the body. They have many functions, including reducing inflammation and suppressing the body's immune system.

Steroid medicines are man-made but are similar to these natural hormones. Oral steroids are steroid medicines taken by the mouth.

Steroid medicines used to treat disease are also called corticosteroids.

The most commonly used corticosteroid medicine type is glucocorticoids. These include steroids such as:

• Prednisolone.

• Betamethasone.

• Dexamethasone.

• Hydrocortisone.

• Methylprednisolone.

• Deflazacort.

The other group are called mineralocorticoids. Mineralocorticoids are usually used for replacing steroids the body isn't producing itself. The one commonly used is fludrocortisone.

Oral steroids are used to treat a large number of conditions, usually by reducing inflammation or the effect of the immune system. Some examples include:

• Inflammatory bowel diseases (for example, morbo di Crohn, colite ulcerosa).

• Autoimmune diseases (for example, lupus eritematoso sistemico (LES), epatite autoimmune).

• Relapses that occur in multiple sclerosis.

• Joint and muscle diseases (for example, artrite reumatoide, polimialgia reumatica).

• Allergie.

• Asma.

• Malattia polmonare ostruttiva cronica (BPCO).

• Croup.

Oral steroids are also used to treat the effects of some cancers or to treat conditions in which a person is not making enough of their own natural steroids (for example, in Addison's disease, congenital adrenal hyperplasia e ipopituitarismo).

This will vary depending on the steroid used and the condition for which they are prescribed. For short courses, usually a relatively high dose is prescribed each day for up to a week, and then stopped abruptly at the end of the course. If oral steroids are taken for longer than this it is important to reduce the dose gradually before stopping.

For those who have to take oral steroids for a longer time, a common treatment plan is to start with a moderately high dose to control symptoms. The dose is then reduced to the lowest daily dose that keeps symptoms away.

The length of treatment can vary, depending on the disease. Sometimes the steroid treatment is gradually stopped if the condition improves, and restarted if it worsens. In some conditions steroids are needed lifelong.

It will depend on which steroid you take, and what it is for. Usually steroids are taken first thing in the morning, with food. The pharmacist will be able to advise further.

A short course of oral steroids usually causes no side-effects. Side-effects are more likely to occur with a long course of oral steroids (more than 2-3 months), or if short courses are taken repeatedly.

The main possible side-effects include the following:

'Assottigliamento' delle ossa (osteoporosi)

If steroids are going to be taken long-term then it is often advised to take medications or supplements to strengthen the bones and help prevent osteoporosis.

Aumento di peso

Weight gain is common on high dose or long-term oral steroids. As well as gaining weight, some people develop puffiness around the face and at the base of the neck.

Increased chance of infections

On long-term or high-dose oral steroids, there is a higher chance of developing an infection, or an infection being more serious, because steroids may suppress the immune system.

In particular, people who have not had chickenpox or measles in the past (and so are not immune) may be advised to avoid people with chickenpox, shingles o morbillo.

Infections which may remain in the body, such as tubercolosi (TB), o herpes, may recur.

Increase in blood pressure

There may be an increase in blood pressure, so it is important for blood pressure to be checked regularly, at least once a year. It can be treated if it becomes high.

High blood sugar (hyperglycaemia)

Steroids can cause raised blood sugar, leading some people to develop diabete. People who already have diabetes may need more medication to control their blood sugar. People on long-term oral steroids are usually advised to have a yearly blood test to check for diabetes

Problemi della pelle

Long-term oral steroids often cause skin problems such as slower healing after injuries, thinning skin, and easy bruising. Stretchmarks sometimes develop.

Debolezza muscolare

Debolezza muscolare can be noticeable on long-term oral steroids but this improves after the steroid is stopped.

Mood and behavioural changes

Some people feel better in themselves when they take steroids, noticing increased energy. However, steroids may aggravate depressione and other serious mental health problems, and may occasionally cause mental health problems.

If this side-effect occurs, it tends to happen within a few weeks of starting treatment and is more likely with higher doses. Occasionally people even become confused; they may develop delusional and suicidal thoughts.

These mental health effects can also occur when steroid treatment is being withdrawn. Medical advice should be sought if worrying mood or behavioural changes occur.

An increased risk of developing cataracts

It is important to have regular eye tests at the optician. An optician's advice should be sought if any sight problems, such as blurred vision, develop. There is an increased risk of developing cataracts.

An increased risk of duodenal ulcers and stomach ulcers

As there is an increased risk of ulcere duodenali e ulcere gastriche, medical advice should be sought if indigestion, acid reflux or tummy (abdominal) pains occur. For people at risk of these conditions, medication may be prescribed to reduce the symptoms and the risk of developing an ulcer.

NOTE: The above are only the main possibile side-effects which may affect alcuni people who take steroids. There is often a balance between the risk of side-effects of oral steroids against the effects of the diseases if not treated. Less common side-effects are not listed above but will be included on the leaflet that comes with the medicine.

There are very few people who cannot take oral steroids.

Oral steroids are used with caution in people who:

• Have liver problems.

• Have a history of severe mental health problems.

• Have a history of ulcere gastriche o ulcere duodenali.

• Hai 'assottigliamento' delle ossa (osteoporosi).

• Have cataracts.

• Have certain heart conditions, such as a recent heart attack, insufficienza cardiaca, o pressione alta (ipertensione).

• Hai diabete.

• Have epilepsy.

• Have systemic sclerosis.

• Siete incinte.

• Are breastfeeding.

It is important to tell a doctor or pharmacist if you are pregnant or may be pregnant, or are breastfeeding.

With a short course of an oral steroid (a week or less), it is usually advised to abruptly stop taking the tablets at the end of the course.

With a longer course, there will be a gradual reduction in dose before stopping.

When not to stop taking oral steroids suddenly

Do not stop taking oral steroids suddenly if you have been taking a dose of 40mg, or higher than this, for more than 1 week or taking lower doses for 3 weeks or more.

It probably does no harm to forget the odd dose. However, there may be serious withdrawal effects once the body is used to the steroids. These may develop within a few days if stopping oral steroids suddenly. Any change in dose should be supervised by a doctor.

Why is it necessary to reduce the dose gradually before stopping oral steroids?

The body makes steroid hormones by itself and these are necessary for the body to function. When taking oral steroids for a few weeks or more, the body reduces or stops making its own steroid hormones.

If the oral steroids are stopped suddenly, the body does not have the hormones it needs to function. This can cause withdrawal symptoms which can be serious and life-threatening. The symptoms can include:

• Debolezza.

• Stanchezza.

• Sensazione di malessere (nausea).

• Essere malato (vomito).

• Perdita di appetito.

• Diarrea.

• Dolore addominale.

• Low blood sugar (ipoglicemia).

• Bassa pressione sanguigna (hypotension) which can cause dizziness, fainting or collapse.

• Developing patches of darker coloured skin.

When the dose is reduced gradually, the body gradually resumes its natural production of steroids and the withdrawal symptoms do not occur.

• Do not take anti-inflammatory painkillers (come ibuprofene) whilst taking steroids (unless advised by a doctor). The two together further increase the risk of a stomach or duodenal ulcer developing

• Most people who take regular steroids carry a steroid card which should be provided by the person who prescribes or supplies your medicine, and/or they wear a medical emergency identification bracelet or equivalent. This gives details of the dose and medical condition in case of emergencies.

• The dose of steroid may need to be increased for a short time if ill with specific conditions, for example, during a serious infection or when undergoing surgery. This is because additional physical stress is placed on the body by these events and therefore higher steroid levels are needed - normally the body would naturally produce these but taking oral steroids switches off the body's normal supply.

Many medicines can affect or be affected by oral steroids. This means the steroid could affect how they work, either resulting in the other medicine being ineffective or having more side-effects than usual. They can also interact the other way around, with the other medicine affecting the corticosteroid.

Examples of medicines which can interact with steroids include:

• Warfarin (a blood-thinning medicine to prevent blood clots).

• Non-steroidal anti-inflammatory drugs (NSAIDs), come ibuprofene, diclofenac e naprossene. Both NSAIDs and steroids can cause gut ulcers as a side-effect, so when taken together, the risk is particularly high. A medicine such as a proton pump inhibitor (PPI) may need to be taken to reduce this risk.

• Live vaccines. Most vaccines do not contain the germ they are protecting against, but a few do. These include the measles, mumps and rubella (MMR) vaccine, rotavirus, yellow fever and tuberculosis (TB). People taking steroid medication and people who are living with those taking steroid medication should avoid live vaccines unless specifically advised otherwise.

• Medicines for epilepsy, specifically carbamazepine, fenitoina e phenobarbital.

• Medicines for diabetes. After starting steroids blood sugars should be tested more frequently, and then the doses of medicines for diabetes can be altered if required

• Digossina.

• 'Water tablets' (diuretics).

• Treatments for HIV and AIDS.

As long as the doctor knows this is being taken, they can advise accordingly.

Usually steroids can safely be used safely in pregnant or breastfeeding women. The lowest dose possible for the shortest possible amount of time would be used. Some, but not all, studies looking at steroid use in the first 12 weeks of pregnancy, showed they may slightly increase the risk of the baby having a cleft lip and/or palate and also might increase the risk of a pre-term birth.

One particular oral steroid (dexamethasone) is often used towards the end of pregnancy if there is a risk of a pre-term birth as it can help the baby's lungs to mature more quickly and improve the baby's chance of survival.